Reversing Alzheimer's, Stroke damage and Parkinsons

TUDCA (Tauroursodeoxycholic acid) is a bile acid derivative naturally found in small amounts in your body, especially in bile. Originally studied for its liver-protective effects, it’s now gaining attention as a mitochondria-supporting, neuro-protective powerhouse.

Here’s a breakdown of what makes TUDCA so exciting, especially in relation to brain and mitochondrial health:

The Mitochondria are the engine of the cell

🔬 What TUDCA Does at a Cellular Level

Supports mitochondrial function: TUDCA helps stabilize the mitochondrial membrane, preventing cell death (apoptosis) triggered by mitochondrial dysfunction.

Reduces ER stress: It’s one of the few known molecules that can relieve endoplasmic reticulum (ER) stress, which is implicated in neurodegenerative diseases, insulin resistance, and even some cancers.

Anti-inflammatory + antioxidant: TUDCA reduces damaging oxidative stress in cells — especially important in the brain.

🧠 Brain Benefits (Backed by Research)

1. 🧠 Stroke Protection

Study: PMID: 12721362

Findings: TUDCA reduced infarct (damage) size by ~50% in animal models of stroke.

How? It suppresses apoptosis (programmed cell death), boosts blood flow, and preserves neuronal function.

2. 🧠 Alzheimer’s Disease Study: PMID: 19935406

Findings: In Alzheimer’s models, TUDCA improved memory, reduced amyloid beta toxicity, and prevented brain cell death.

3. 🧠 Parkinson’s Disease

Study: PMID: 22773138

Findings: TUDCA rescued dopamine neurons — the very cells that die off in Parkinson’s — and improved motor behavior in mice.

4. 🧠 Brain Blood Flow & Barrier Protection

Study: PMID: 31778648

TUDCA helps maintain blood-brain barrier integrity and increases cerebral blood flow, both critical for preventing neuro-degeneration.

🧬 Why It’s a Mitochondrial Ally

Many chronic conditions — from brain fog to full-blown neuro-degenerative diseases — involve mitochondrial dysfunction. TUDCA:

Shields mitochondria from oxidative stress

Restores ATP production (cellular energy)

Prevents mitochondrial-triggered apoptosis

Helps detox damaged cells by improving cell signalling

💊 Should You Supplement?

TUDCA is available as a dietary supplement, usually dosed between 250–1,500 mg/day, depending on the condition. It's often stacked with NAC, CoQ10, or PQQ for broader mitochondrial support.

⚠️ Caution: Though generally considered safe, high doses may cause GI upset. Always check for liver conditions or gallbladder issues with a healthcare provider.

🧠 Bottom Line

TUDCA isn’t just a liver supplement — it’s a mitochondrial modulator and brain defender. If you’re looking at long-term cognitive health, neuro-protection, or mitochondrial recovery (from stress, toxins, or aging), TUDCA is one of the most promising compounds available. Sources: https://pubmed.ncbi.nlm.nih.gov/12721362/ https://www.sciencedirect.com/science/article/abs/pii/S1471491408000026 https://pubmed.ncbi.nlm.nih.gov/22773138/ https://pubmed.ncbi.nlm.nih.gov/19935406/ https://pubmed.ncbi.nlm.nih.gov/31778648/